Profile

PhD (Jinan University), Associate Professor. Her research focus is on the quorum sensing inhibitors,biofilm inhibitors,and design and synthesis of anti-infection drugs. Currently, she is holding over 1 NSFC grant, 1 China Postdoctoral Science Foundation. As of April 2024, she has published more than 17 peer-reviewed papers in international journals, of which 8 she serves as the first authors, mainly in top journals such as J. Med. Chem.，Eur. J. Med. Chem.,she has also applied for 8 invention patents, 3 of which have been licensed.

Education& Professional Experience：

2024.04-present

Associate Professor, Institute for Advanced and Applied Chemical Synthesis, Jinan University

2022.06-2024.04

Post-doctoral Research Fellow

College of Pharmacy, Jinan University Affiliated First Hospital, Guangzhou, China

2019.09-2022.06

PhD in Medicine (Specialty: Chinese Medicinal Chemistry)

College of Pharmacy, Jinan University, Guangzhou, China

2016.09-2019.06

Master of Medicine (Specialty: Medicinal Chemistry)

College of Pharmacy, Jinan University, Guangzhou, China

Research Interests:

(1)   The discovery and mechanism research of bacterial quorum sensing and bacterial biofilm inhibitors

(2)   Design and synthesis of novel anti-infective drugs

Professional Organizations:

(1)   Committee Member - Chiral Drugs Committee of Guangdong Pharmaceutical Society

(2)   Committee Member -Expert Committee for Health Technology Promotion of China National Health Association

Research grant support:

(1)   National Natural Science Foundation of China (82304274), Study on Molecular Probe and Target of Dual-acting Biofilm Inhibitor with both Iron Chelation and Quorum Sensing.

(2)   China Postdoctoral Science Foundation (No. 55350658),Design, synthesis, and mechanism study of quorum sensing biofilm inhibitors as antimicrobial agents against drug-resistant bacteria.

Representative Publications：

(1)     Liu, Jun§; Zhao, Si-Yu§; Hu, Jia-Yi; Chen, Qiu-Xian; Jiao, Shu-Meng; Xiao, Hai-Chuan; Zhang, Qiang; Xu, Jun; Zhao, Jian-Fu*; Zhou, Hai-Bo*; Zheng, Jun-Xia*; Sun, Ping-Hua*. Novel coumarin derivatives inhibit the quorum sensing system and iron homeostasis as antibacterial synergists against Pseudomonas aeruginosa. Journal of Medicinal Chemistry. 2023, 66, 14735-14754. 

(2)     Liu, Jun§; Hou, Jin-Song§; Chang, Yi-Qun; Peng, Li-Jun; Zhang, Xiao-Yi; Miao, Zhi-Ying; Sun, Ping-Hua*; Lin, Jing*; Chen, Wei-Min*. New Pqs quorum sensing system inhibitor as an antibacterial synergist against multidrug-resistant Pseudomonas aeruginosa. Journal of Medicinal Chemistry.2022, 65, 688-709. 

(3)     Liu, Jun; Hou, Jin-Song; Li, Yi-Bin; Miao, Zhi-Ying; Sun, Ping-Hua*; Lin, Jing*; Chen, Wei-Min*. Novel 2-substituted 3-hydroxy-1,6-dimethylpyridin-4(1H)-ones as dual-acting biofilm inhibitors of Pseudomonas aeruginosa. Journal of Medicinal Chemistry. 2020, 63, 10921-10945. 

(4)     Liu, Jun; Meng, Ying; Yang, Ming-Han; Zhang, Xiao-Yi; Zhao, Jian-Fu*; Sun, Ping-Hua*; Chen, Wei-Min*. Design, synthesis and biological evaluation of novel 3-hydroxypyridin-4(1H)-ones based hybrids as Pseudomonas aeruginosa biofilm inhibitors. European Journal of Medicinal Chemistry. 2023, 259, 115665. 

(5)     Liu, Jun; Chen, Qiu-Xian; Wu, Wen-Fu; Wang, Dong; Zhao, Si-Yu; Li, Jia-Hao; Chang, Yi-Qun; Zeng, Shao-Gao; Hu, Jia-Yi; Li, Yu-Jie; Du, Jia-Xin; Jiao, Shu-Meng; Xiao, Hai-Chuan; Zhang, Qiang; Xu, Jun; Zhao, Jian-Fu; Zhou, Hai-Bo*; Wang, Yong-Heng*; Zou, Jian*; Sun, Ping-Hua*. Novel ligustilide derivatives target quorum sensing system LasR/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection. European Journal of Medicinal Chemistry.2024, 263, 115972. 

(6)     Li, Yi-Bin§; Liu, Jun§; Huang, Zhi-Xing; Yu, Jia-Hui; Xu, Xiao-Fang; Sun, Ping-Hua; Lin, Jing*; Chen, Wei-Min*. Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors. European Journal of Medicinal Chemistry. 2018, 158, 753-766. 

Contact：

Address: Jinan University,the Second Science and Technology Building

Email:  liujun8696@jnu.edu.cn