Profile

PhD (Monash University), Associate Professor, Master degree supervisor. His research interests mainly focus on medicinal chemistry and synthetic methodologies. He was experienced in drug discovery and commercialization, two projects in which he participated were successfully attracted more than 2.7 millions dollar investment during the working period at Australian Translational Medicinal Chemistry Facility (ATMCF). As of July 2023, he has published more than 17 peer-reviewed papers in international journals, of which 4 he serves as the first authors, mainly in top journals such as Nature Communications (IF: 17.69), Journal of the American Chemical Society (IF: 16.38), and Advanced Synthesis & Catalysis (IF: 5.38).

Education& Professional Experience：

2023.07-present

Associate Professor, Institute for Advanced and Applied Chemical Synthesis, Jinan University

2019.10-2023.07

Research Fellow

School of Pharmacy & Australian Translational Medicinal Chemistry Facility (ATMCF), Monash University, Australia

2018.10-2019.10

Research Fellow

School of Chemistry, Monash University, Australia

2015.04-2018.10

PhD in Chemistry (Specialty: Organic Chemistry)

School of Chemistry, Monash University, Australia

2010.09-2013.06

Master of Science (Specialty: Medicinal Chemistry)

School of Pharmacy, Fudan University, Shanghai, China

2006.09-2010.06

Bachelor of Science

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China

Representative Publications in Recent 5 Years：

1.     Jin, J.; Zhao, Y.; Kyne, S. H.; Farshadfar, K.; Ariafard, A.*; Chan, P. W. H.* Copper(I)-catalysed site-selective C(sp3)–H bond chlorination of ketones, (E)-enones and alkylbenzenes by dichloramine-T. Nat. Commun. 2021,12 (1), 4065.(Impact factor 17.69)

2.     Jin, J.;Zhao, Y.; Gouranourimi, A.; Ariafard, A.*; Chan, P. W. H.* “Chiral Brønsted Acid Catalyzed Enantioselective Dehydrative Nazarov-type Electrocyclization of Aryl and 2-Thienyl Vinyl Alcohols”,J. Am. Chem. Soc. 2018, 140, 17, 5834–5841.(Highlighted by SYNFACTS, Synfacts 2018, 14, 760; Highlighted by Chemistry in Australia, Chem. Aust. 2018, July, 14. Impact factor 16.38)

3.     Jin, J.;Zhao, Y.; Sze, E. M. L.; Kothandaraman, P.; Chan, P. W. H.* “Chiral Brønsted Acid and Gold Catalyzed Enantioselective Synthesis of 1,8-Dihydroindeno[2,1-b]pyrroles”, Adv. Synth. Catal.2018, 360, 24, 4744–4753. (Selected as VIP paper, Impact factor 5.83)

4.      Ling, V. Y.; Straube, J.; Godfrey, W.; Haldar, R.; Janardhanan, Y.; Cooper, L.; Bruedigam, C.; Cooper, E.; Tavakoli Shirazi, P.; Jacquelin, S.; Tey, S.-K.; Baell, J.; Huang, F.; Jin, J.; Zhao, Y.; Bullinger, L.; Bywater, M. J.; Lane, S. W., Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia. Leukemia 2023,37 (1), 143-153.(Impact factor 11.53)

5.      Zhao, Y.; Merrett, J. T.; Jin, J.; Yu, L.-J.; Coote, M. L.; Chan, P. W. H., Gold catalysed site-selective cross-coupling of tertiary α-silylamines with 1-iodoalkynes under UVA LED light. Org. Chem. Front.2023, 10, 759–766.(Impact factor 5.28)

6.      Pitcher, N. P.; Harjani, J. R.; Zhao, Y.; Jin, J.; Knight, D. R.; Li, L.; Putsathit, P.; Riley, T. V.; Carter, G. P.; Baell, J. B., Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract. ACS Omega 2022, 7 (8), 6737-6759.(Impact factor 4.13)

7.      Zhao, Y.; Bruce, L. D.; Jin, J.; Xia, B.*; Chan, P. W. H.* Copper catalyzed N-formylation of α-silyl-substituted tertiary N-alkylamines by air. Green Chem, 2020, 22, 5296–5302.2. (Selected as an inside cover work; impact factor 10.18)

8.      Li, G.; Henry, S. A.; Liu, H.; Kang, T.-S.; Nao, S.-C.; Zhao, Y.; Wu, C.; Jin, J.; Zhang, J.-T.; Leung, C.-H.; Chan, P. W. H.*; Ma, D.-L.*, A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer. Chem. Sci. 2020,11, 1750–1760.(Selected as an Edge Article and Front Cover Picture; impact factor 9.96)

9.      Chen, X.; Zhou, Y.; Jin, J.; Farshadfar, K.; Ariafard, A.; Rao, W.*; Chan, P. W. H.* Gold Catalyzed Cyclopropanation/[5+3] Cycloaddition of 1,4,9- and 1,4,10-Allenenynes to Bicyclo[3.3.1]nonane Derivatives. Adv. Synth. Catal. 2020, 362, 1084. 1.(Impact factor 5.83)

10.  Zhao, Y.; Henry, S. A; Jin, J;Clarkson, G. J.; Chan, P. W. H.* “Brønsted Acid-Catalyzed Cyclization of β-Amino-1,4-enols to Oxazol-2(3H)-ones and 5-Alkenyloxazolidin-2-ones”, Asian J. Org. Chem.2019, 8, 1029–1032.（invited paper for special issue）

11.  Zhao, Y.; Jin, J.;Chan, P. W. H.* “Gold Catalyzed Photoredox C1-Alkynylation of N-Alkyl-1,2,3,4 Tetrahydroisoquinolines by 1-Bromoalkynes with UVA LED Light”,  Adv. Synth. Catal.2019, 361, 6, 1313–1321.（Selected as an Edge Article and Front Cover Picture; impact factor 5.98)

Research interests：

1. Medicinal chemistry: discovery of novel small molecular drugs for tumors and metabolic diseases.

2. Organic chemistry: synthetic methodologies, radical chemistry, and asymmetric chemistry.

Contact：

The Second Science and Technology Building, Jinan University, Guangzhou